TABLE 2

Genes differentially expressed in liver in diabetic BTBR-ob/ob mice

AccessionDescriptionFoldP
Downregulated in BTBR-ob/ob
 Lipogenesis
  X13135Fatty acid synthase−1.40.0032
  M21285Stearoyl-coenzyme A desaturase 1−1.5<0.0001
  U11680Glycerol-3-phosphate acyltransferase−1.6<0.0001
  J02652Malic enzyme−1.50.0269
  Z19521LDL receptor−1.40.0258
  X95279SPOT14 homolog−1.6<0.0001
  AB016248Sterol-C5-desaturase−2.5<0.0001
  U28960Phospholipid transfer protein−2.1<0.0001
 Metabolism
  M21855Cytochrome P450, 2b9−2.0<0.0001
  X63023Cytochrome P450 3a13−1.9<0.0001
  M21856Cytochrome P450, 2b10−1.9<0.0001
  AW047343D site albumin promoter binding protein−2.6<0.0001
  U89906α-methylacyl-CoA racemase−1.9<0.0001
  AI047508Arylacetamide deacetylase−1.6<0.0001
  Y12887Carboxylesterase 1−1.6<0.0001
  AJ132098Vanin 1/panletheinase−1.50.0016
  AI326397Glutathione S-transferase, mu 6−1.7<0.0001
  M88694Thioether S-methyltransferase−1.7<0.0001
  AB027012Galactokinase−1.60.0029
  M63245Amino levulinate synthase (ALAS-H)−1.40.0022
 Immune response
  M35525Hemolytic complement (C5)−4.2<0.0001
  D89290CD151 antigen−2.8<0.0001
  AF001277Chemokine (C-C) receptor 8−1.9<0.0001
  AI854154ACP33 (acidic cluster protein 33)−1.70.0008
  D64162Rae1−1.7<0.0001
  M27008Orosomucoid 1−1.5<0.0001
  M13521Serum amyloid A 1−1.9<0.0001
  U60438Serum amyloid A 2−1.40.0091
 Extracellular matrix
  U03419Procollagen, type 1, alpha 1−2.4<0.0001
  X52046Procollagen, type III, alpha 1−1.90.0101
  X15986Lectin, galactose binding, soluble 1−2.7<0.0001
 Signal transduction
  U94828Regulator of G-protein signaling 16−1.50.0002
  AF041376DNA fragmentation factor−2.5<0.0001
  AV115237Translation initiation factor 4E−2.8<0.0001
  X83577Glypican 4−1.90.0009
 Others
  AV355798Major urinary protein 1−1.8<0.0001
  AI255271Major urinary protein 1−1.5<0.0001
  M16357Major urinary protein 3−1.8<0.0001
  M16358Major urinary protein 4−1.40.0134
  M16360Major urinary protein 5−1.40.0466
  AF018952Aquaporin 8−1.50.0024
  AI120514Sulfate anion transporter (sat-1)−1.80.0001
  X05862Mouse H2B histone gene−2.5<0.0001
  AI848902Ribosomal protein L14 (60S subunit)−2.00.0020
  M64292B-cell translocation gene 2−1.8<0.0001
  AB003305Proteasome subunit, beta type 5−1.7<0.0001
  AI530403DNA segment ERATO Doi 25, expressed−1.50.0009
Upregulated in BTBR-ob/ob
 Immune response/signal transduction
  X03505Serum amyloid A33.6<0.0001
  D00725Serine protease inhibitor 22.0<0.0001
  X05475Complement component 91.5<0.0001
  AF031127Inositol trisphosphate receptor 2 (Itpr2)1.70.0228
  AW049716Epidermal growth factor receptor1.60.0006
  AI835443c-myc, exon 21.50.0141
  AB012808Organic cation transporter1.9<0.0001
 Structure
  Y07711Zyxin2.1<0.0001
  AF020185Dynein, cytoplasmic, light chain 11.60.0004
  L31397Dynamin1.40.0387
 Others
  M58567Hydroxysteroid dehydrogenase-12.6<0.0001
  AF059177Avian erythroblastosis oncogene B 42.7<0.0001
  AV368725Fragile X mental retardation gene2.2<0.0001
  M17327Provirus envelope protein1.9<0.0001
  AV084197Activating transcription factor 31.90.0002
  D13803RecA-like protein murine Rad511.9<0.0001
  AJ009840Cathepsin E/lysosomal protease1.60.0032
  X91864Glulathione peroxidase 21.50.0002
  AI840339Ribonuclease, RNase A family 41.50.0004