TABLE 3

Genes differentially expressed in skeletal muscle in diabetic BTBR-ob/ob mice

AccessionDescriptionFoldP
Downregulated in BTBR-ob/ob
 Structure
  AV359510Actinin alpha 3−2.3<0.0001
  AF093775Actinin alpha 3−1.8<0.0001
  J04992Troponin 1, skeletal, fast 2−1.5<0.0001
  AJ223361Myosin heavy chain 2B−3.4<0.0001
  AJ002522Myosin heavy chain 2X−1.7<0.0001
  U04541Tropomyosin 5−1.7<0.0001
 Others
  X59382Parvalbumin−3.8<0.0001
  X05862H2B histone gene−3.1<0.0001
  AI850569Pyrroline 5-carboxylate reductase−2.2<0.0001
  AV336704Semaphorin 3B−1.90.0001
  M36411Mpv17, glomerulosclerosis−2.0<0.0001
  C78850Envelope protein (env) gene−2.0<0.0001
  AW049373TCP-1 epsilon subunit−1.8<0.0001
  M17192Homeobox protein A7 (Hox-A7)−1.70.0004
  AB003305Proteasome subunit, beta type 5−1.8<0.0001
  U67188Regulator of G-protein signaling 5−1.70.0003
  AB024922Sarcoglycan, gamma−1.6<0.0001
  AF084482Wolfram syndrome gene−1.60.0001
  A1843119Glutathione S-transferase like−1.5<0.0001
  AV338260Retinoblastoma 1−1.50.0007
  U07950GDP dissociation inhibitor 1−1.40.0124
Upregulated in BTBR-ob/ob
 Adipocytes specific genes
  U49915Acrp30/adiponectin1.6<0.0001
  M20497aP21.6<0.0001
  AI326963Fasting induced adipose factor3.8<0.0001
  AA797604Fasting induced adipose factor1.60.0002
  Y14004Acyl-CoA thioesterase 1, cytosolic1.6<0.0001
  M21285Stearoyl-coenzyme A desaturase 12.1<0.0001
  U69543Hormone sensitive lipase1.50.0033
 Metabolism
  AV255366Ornithine decarboxylase2.2<0.0001
  AI837005Cdv31.40.0001
  Z49204Nicotinamide nucleotide transhydrogenase1.7<0.0001
  X16670Carbon catabolite repression 4 homolog1.60.0005
  X04120Carbon catabolite repression 4 homolog1.50.0018
  K02236Metaliothionein 21.5<0.0001
 Structure
  U68267Myosin-binding protein H1.50.0047
  AF020185Dynein, cytoplasmic, light chain 11.7<0.0001
  AV062363Synuclein, gamma1.60.0007
  AA839903Myosin light chain-2 isoform MLC-2a1.6<0.0001
  J04953Gelsolin1.40.0055
  AF051945Cardiac morphogenesis1.5<0.0001
  L08407Procollagen, type XVII, alpha 11.80.0009
 Others
  M64086Serine protease inhibitor 2-22.3<0.0001
  AI848330DNA segment ERATO Doi 689, expressed1.9<0.0001
  U19118Activating transcription factor 31.7<0.0001
  AF038939Paternally expressed gene 31.6<0.0001
  AI854779Nuclear ribonucleoprotein A/B1.60.0005
  M17551Intracisternal A-particle gag protein1.30.0050