TABLE 4

Genes differentially expressed in pancreatic islets diabetic BTBR-ob/ob mice

AccessionDescriptionFoldP
Downregulated in BTBR-ob/ob
  AF003525Defensin beta 1−4.2<0.0001
  AW050141Adracalin−3.0<0.0001
  X04573Elastase 2−2.8<0.0001
  AF009513Plasma glutamate carboxypeptidase−2.00.0012
  M13660Interferon alpha family, gene 9−2.20.0001
  X13333CD14 antigen−5.6<0.0001
  X05862H2B histone gene−2.2<0.0001
  AW121609ATP-binding cassette, sub-family B12−2.00.0010
  M62374γ-aminobutyric acid receptor−1.80.0388
  AF088983Heat shock protein cognate 40−1.80.0213
  L34214Regulated endocrine-specific protein 18−1.80.0067
Upregulated in BTBR-ob/ob
 Metabolism
  AW124932HMG-CoA synthase1.80.0165
  X95279SPOT141.90.0013
  U05809Transketolase2.40.0145
  AA879764NADH:ubiquinone oxidoreductase2.1<0.0001
  AI846934Lipin 12.5<0.0001
  AI790931Fructose-1, 6-bisphosphatase 15.1<0.0001
  D42083Fructose-1, 6-bisphosphatase 23.30.0005
  L09104Glucose phosphate isomerase 12.1<0.0001
  AF007267Phosphomannomutase 14.6<0.0001
  AV318100Glucosidase 12.3<0.0001
  U75215Neutral amino acid transporter2.3<0.0001
  U24428Glulathione S-transferase, mu 51.80.0197
 Secretory proteins
  X59520Cholecystokinin8.7<0.0001
  AE000665Trypsin 23.5<0.0001
  AE000663Trypsin-like serine protease6.3<0.0001
  K02782Complement component 32.4<0.0001
  X06342Serine protease inhibitor, Kazal type 33.7<0.0001
  D63359Pancreatitis-associated protein2.9<0.0001
 Signal transduction
  AI845798Phospholipase A22.5<0.0001
  AI642389ER lumen protein retaining receptor 31.90.0032
  AW048937CDK inhibitor 1A (P21)1.80.0172
  AI196645Rap7a1.70.0064
 Extracellular matrix
  AI527354Fibronectin 13.4<0.0001
  AV374020Keratin complex 1, acidic, gene 102.7<0.0001
  U03419Procollagen, type 1, alpha 12.20.0243
  U66166Extracellular matrix protein 22.2<0.0001
 Others
  U48398Aquaporin 41.80.0200
  AI851345Septin 72.30.0001
  X52643Histocompatibility 2A, alpha2.70.0006
  X61454I3 protein2.2<0.0001
  AJ243851LIM homeobox protein 92.1<0.0001
  U19118Activating transcription factor 32.00.0001
  X96518Homeo box, msh-like 32.00.0001
  L26479Translation elongation factor 1 alpha 21.90.0001
  AJ242663Cathepsin Z1.80.0497
  M89797MMTV integration site 41.90.0024
  AI854482Mouse jerky gene (Jh8), epilepsy gene1.70.0119