TABLE 4

Physical properties of L-E rats used for studies with lipoic acid and LY333531

Nondiabetic rats
Diabetic rats
ControlLipoic acidLY333531ControlLipoic acidLY333531
n151415201716
Initial body weight (g)223.7 ± 20.9237.1 ± 17.0227.0 ± 15.9224.8 ± 11.2227.4 ± 13.1216.9 ± 19.4
Final body weight (g)305.3 ± 18.9*291.8 ± 11.5*307.7 ± 22.9*247.3 ± 21.9*235.6 ± 15.9*242.8 ± 27.6*
Blood glucose (mg/dl)96.9 ± 11.094.1 ± 8.2101.1 ± 8.7355.3 ± 51.4351.8 ± 48.6380.3 ± 54.8
AT (s)1.55 ± 0.441.42 ± 0.241.40 ± 0.361.58 ± 0.381.55 ± 0.271.51 ± 0.59
Artery diameter (pixels)6.5 ± 0.47.1 ± 0.47.0 ± 0.56.7 ± 0.56.9 ± 0.66.6 ± 0.5
Vein diameter (pixels)8.7 ± 0.48.7 ± 0.58.5 ± 0.58.3 ± 0.88.8 ± 0.78.3 ± 0.4
  • Data are means ± SD.

  • *

    * P < 0.05 compared with initial body weight (paired t-test);

  • P < 0.01 compared with nondiabetic control rats.