Body composition details
| 56-year-old female, P467L (S1) | 32-year-old male, P467L (S2) | 21-year-old female, V290M (S3) | Healthy adult ranges | |
|---|---|---|---|---|
| Height (m) | 1.53 | 1.72 | 1.64 | |
| Weight (kg) | 57.1 | 73.8 | 75.8 | |
| BMI (kg/m2) | 24.4 | 24.9 | 28.1 | 18.5–24.9 (44) |
| Predicted total body fat (%)* | 29.0 | 22.0 | 34.5 | |
| Measured total body fat (%) | 17.6 | 10.6 | 25.5 | S1: 23–34% |
| S2: 8–20% | ||||
| S3: 33–39% (45) | ||||
| Waist-to-hip ratio | 1.1 | 0.91 | 0.99 | Female <0.85 |
| Male <1.0 | ||||
| Visceral fat-to-total abdominal fat ratio | 0.28 | 0.44 | 0.39 | Female 0.25 ± 0.14 |
| Male 0.42 ± 0.11 (46) | ||||
| Fatty liver† | + | + | + | |
| IMTGs expressed as IMTG-to-creatine ratio for soleus muscle | 13.7 | 9.7 | — | Mean ± SE in 76 control subjects = 13.6 ± 6.6 (E.L.T., J.D.B., unpublished data) |
* Predicted body fat was calculated as follows (47): men % fat = (1.281 × BMI) − 10.13; women % fat = (1.48 × BMI) − 7.00.
† The diagnosis of fatty liver (+) was made on the basis of an echo-bright ultrasound picture in the absence of a history of alcohol consumption in excess of 40 g per week. Steatosis and cirrhosis were confirmed histologically in S1.