TABLE 2

Response to PPAR-γ agonist therapy (4 mg rosiglitazone b.i.d.)

P467L (S2)
V290M (S3)
Reference
Months of treatment01360136
Weight (kg)73.876.875.876.6
Fat mass (kg)6.39.817.621.6
Leptin (μg/l)0.71.51.91.911.213.814.414.4*
Acrp30 (units/ml)0.250.50.170.242.23 ± 0.66 (32)
Blood pressure (mmHg)140/97147/84153/85156/99136/84114/82135/88140/85
Glucose (mmol/l)1010.9129.39.67.36.47.23.5–6.3
Insulin (pmol/l)8510773114411265414410<80
HbA1c (%)8.78.88.35.67.36.96.77.14.9–6.3
Glucose disposal (mg · kg−1 · min−1)7.5314.92.913.2113–15 (14)
Hepatic glucose output (mg · kg−1 · min−1)1.0700.310.520
Triglycerides (mmol/l)5.76.67.66.34.57.13.56.9<2.0
HDL cholesterol (mmol/l)0.580.720.660.790.580.710.720.52>0.9
NEFAs (mmol/l)503365510325558915852643280–920
Alanine aminotranferase (units/l)858710882394879580–50
γ-Glutamyl transferase (units/l)687586671471001021220–50
  • *

    * Leptin adult reference values (unpublished data, mean, and 95% CIs): females: BMI 25–30 kg/m2, n = 348 adults, 21.1 (8.6–38.9); males: BMI <25 kg/m2, n = 278 adults, 3.3 (0.4–8.3).