Antioxidant enzyme and aldose reductase mRNA levels with respect to 5′ALR2 genotype in patients with diabetic nephropathy
| CAT | CuZnSOD | GPX | MnSOD | ALR2 | |
|---|---|---|---|---|---|
| Z − 2/X (n = 15) | 0.4 ± 0.04* | 0.3 ± 0.02†‡ | 0.4 ± 0.03§ | 0.8 ± 0.02 | 4.7 ± 0.8 |
| Z + 2/Y (n = 3) | 0.6 ± 0.08 | 1.7 ± 0.47 | 0.6 ± 0.05 | 0.8 ± 0 | 2.0 ± 0.5 |
| Z − 2/Z + 2 (n = 3) | 0.5 ± 0.05 | 1.3 ± 1.05 | 0.4 ± 0 | 0.6 ± 0.2 | 4.4 ± 3.6 |
| X/Y (n = 5) | 0.6 ± 0.05 | 0.5 ± 0.07 | 0.7 ± 0.08 | 0.9 ± 0.02 | 3.4 ± 1.1 |
Data are mean fold increases ± SE of the PBMCs exposed to hyperglycemia versus those cultured under normal conditions. X, any allele other than Z + 2; Y, any allele other than Z − 2.
* versus CAT X/Y, P = 0.02.
† versus CuZnSOD Z + 2/Y, P < 0.001.
‡ versus CuZnSOD Z − 2/Z + 2, P = 0.009.
§ versus GPX Z + 2/Y, P = 0.02.