TABLE 1

Frequencies of IRS-1 Gly972Arg dimorphism in type 1 diabetic patients and control subjects

Control subjectsType 1 diabetic patientsType 1 diabetic patients with high/moderate risk HLA genotype*Type 1 diabetic patients with low risk HLA genotypes
Genotypes
n243307192115
 Gly/Gly223 (92)250 (81)156 (81)94 (82)
 Gly/Arg20 (8)54 (18)35 (18)19 (16)
 Arg/Arg3 (1)1 (1)2 (2)
Phenotypes§
 Arg positive20 (8)57 (19)36 (19)21 (18)
 Arg negative223 (92)250 (81)156 (81)94 (82)
  • Data are n (%).

  • *

    * DR3/DR4-DQB1 0302, DR3/DR3 and DR4-DQB1 0302/X;

  • DR3/DRX, DRX/DRX DRX = neither DR3 or DR4-DQB1 0302;

  • 2 × 3 contingency table P = 0.016 (control subjects vs. type 1 diabetic subjects).

  • §

    § 2 × 2 contingency table P = 0.0008; OR = 2.5; 95% CI = 1.5–4.3 (control subjects vs. type 1 diabetic subjects).