TABLE 1

Demographic and clinical characteristics in long-standing normoalbuminuric type 1 diabetic patients

Normal GFR groupLow GFR groupP
n8223
Sex (male/female)36/464/190.021
Age (years)35.2 ± 9.536.0 ± 8.0NS
Age at diabetes onset (years)12.9 ± 7.011.3 ± 7.9NS
Diabetes duration (years)22.2 ± 9.624.6 ± 8.0NS
HbA1c (%)8.5 ± 1.68.4 ± 1.1NS
Serum creatinine (mg/dl)*0.84 ± 0.170.96 ± 0.210.005
SBP (mmHg)119.8 ± 10.9116.8 ± 12.9NS
DBP (mmHg)71.2 ± 7.871.7 ± 7.3NS
MBP (mmHg)87.6 ± 8.286.5 ± 8.4NS
Hypertension (yes/no)27/5511/12NS
Antihypertensive treatment (yes/no)13/699/140.022
ACEI or AIIRB (yes/no)4/783/20NS
GFR (ml · min−1 · 1.73 m−2)121.2 ± 16.675.9 ± 11.7ND
AER (μg/min)7.7 (2.8–19.9)7.7 (2.0–17.6)NS
Retinopathy (none/background/proliferative)33/31/152/11/100.006
  • Data are means ± SD, n, and median (range). ACEI, ACE inhibitor; AIIRB, angiotensin II type 1 receptor blocker; DBP, diastolic blood pressure; MBP, mean blood pressure; SBP, systolic blood pressure.

  • *

    * To convert values to μmoles/l, multiply by 88.4;

  • to convert values to ml/s, multiply by 0.01667.