TABLE 3

Neurogenic (autonomic) symptom scores during hyperinsulinemic euglycemic and stepped hypoglycemic clamps in nondiabetic subjects and hyperinsulinemic stepped hypoglycemic clamps in patients with type 1 diabetes

Time (min)Nondiabetic
Diabetic Hypoglycemia
EuglycemiaHypoglycemia
MorningNight awakeNight asleepMorningNight awakeNight asleep
−153 ± 12 ± 22 ± 13 ± 11 ± 02 ± 14 ± 1
02 ± 11 ± 13 ± 13 ± 11 ± 02 ± 13 ± 1
302 ± 11 ± 14 ± 23 ± 21 ± 02 ± 14 ± 1
603 ± 12 ± 15 ± 23 ± 22 ± 13 ± 13 ± 1
903 ± 13 ± 26 ± 33 ± 23 ± 13 ± 14 ± 1
1203 ± 13 ± 25 ± 23 ± 23 ± 13 ± 14 ± 1
1504 ± 13 ± 25 ± 35 ± 33 ± 13 ± 13 ± 1
1804 ± 14 ± 25 ± 33 ± 15 ± 2
2104 ± 16 ± 28 ± 33 ± 15 ± 1
2405 ± 27 ± 210 ± 44 ± 15 ± 1
2706 ± 29 ± 214 ± 36 ± 26 ± 2
3004 ± 112 ± 214 ± 28 ± 25 ± 2
  • Data are means ± SE. Subjects were studied in the morning (0730–1230) and during the night (2100–0200) while awake and asleep (0000–0200). n = 8 for both groups.