TABLE 5

Blood lactate concentrations (μmol/l) during hyperinsulinemic euglycemic and stepped hypoglycemic clamps in nondiabetic subjects and hyperinsulinemic stepped hypoglycemic clamps in patients with type 1 diabetes

Time (min)Nondiabetic
Diabetic Hypoglycemia
EuglycemiaHypoglycemia
MorningNight awakeNight asleepMorningNight awake*Night asleep
−15715 ± 253854 ± 82686 ± 52597 ± 66630 ± 127723 ± 132*624 ± 33
0391 ± 138717 ± 66632 ± 23528 ± 75597 ± 95678 ± 116*571 ± 33
30312 ± 110905 ± 58818 ± 15814 ± 80774 ± 87711 ± 83*775 ± 39
60220 ± 781,354 ± 1101,120 ± 1101,032 ± 120984 ± 98772 ± 97*911 ± 81
90249 ± 881,164 ± 581,007 ± 871,008 ± 93956 ± 126731 ± 73*895 ± 65
120511 ± 1811,099 ± 73832 ± 67968 ± 921,015 ± 93709 ± 74*902 ± 87
150471 ± 1661,108 ± 132771 ± 62896 ± 83975 ± 115671 ± 66*805 ± 87
180353 ± 1251,114 ± 107801 ± 110814 ± 85965 ± 116619 ± 76*773 ± 82
210249 ± 881,184 ± 1251,007 ± 121896 ± 1121,007 ± 110618 ± 71736 ± 65
240298 ± 1051,207 ± 1591,193 ± 134948 ± 121921 ± 118667 ± 73666 ± 59
270288 ± 1091,427 ± 1721,491 ± 1851,192 ± 190930 ± 77770 ± 69*622 ± 61
300373 ± 1311,632 ± 2231,810 ± 2631,564 ± 2831,037 ± 102665 ± 88668 ± 67
  • Data are means ± SE. Subjects were studied in the morning (0730–1230) and during the night (2100–0200) while awake and asleep (0000–0020). n = 8 for both groups.

  • *

    * P = 0.0976 vs. morning;

  • P = 0.0130 vs. morning, P = 0.0038 vs. night awake.