TABLE 6

Serum nonesterified fatty acid concentrations (μmol/l) during hyperinsulinemic euglycemic and stepped hypoglycemic clamps in nondiabetic subjects and hyperinsulinemic stepped hypoglycemic clamps in patients with type 1 diabetes

Time (min)Nondiabetic
Diabetic Hypoglycemia
EuglycemiaHypoglycemia
MorningNight awakeNight asleepMorningNight awakeNight asleep
−15470 ± 52539 ± 50709 ± 90655 ± 61290 ± 58377 ± 102385 ± 68
0458 ± 47506 ± 33718 ± 73649 ± 53302 ± 44397 ± 106371 ± 69
30211 ± 59255 ± 65361 ± 80306 ± 66113 ± 14156 ± 47133 ± 22
6097 ± 2486 ± 21177 ± 48165 ± 6663 ± 1189 ± 2096 ± 13
9085 ± 2083 ± 21198 ± 54103 ± 2160 ± 1072 ± 2177 ± 8
12083 ± 1875 ± 20127 ± 2585 ± 2165 ± 1062 ± 1966 ± 11
15082 ± 2162 ± 14103 ± 2290 ± 2354 ± 857 ± 1884 ± 11
18066 ± 1658 ± 1699 ± 1887 ± 2356 ± 958 ± 1973 ± 10
21062 ± 1368 ± 1796 ± 1882 ± 2054 ± 845 ± 1047 ± 7
24062 ± 1268 ± 22100 ± 2267 ± 1954 ± 1455 ± 1443 ± 11
27053 ± 1286 ± 25132 ± 27104 ± 2561 ± 1454 ± 1554 ± 5
30053 ± 12103 ± 29154 ± 29133 ± 3274 ± 2381 ± 2352 ± 12
  • Data are means ± SE. Subjects were studied in the morning (0730–1230) and during the night (2100–0200) while awake and asleep (0000–0200). n = 8 for both groups.