TABLE 2

Xenospecificity

Islet grafts in the athymic miceObservation time after transfer (days)No. of animalsRejection after transfer
ICC123Yes
Syngeneic B6 islets12No
ICC125Yes
Allogeneic BKs islets12No
ICC126Yes
Concordant xenogeneic rat islets12No incomplete
  • Transfer from immunocompetent B6 mice to athymic B6 (nu/nu) mice bearing a tolerated ICC xenograft together with syngeneic B6 islets, allogeneic BKs islets, or concordant xenogeneic rat islets placed under the kidney capsule of the same kidney but at different locations.