TABLE 3

MHC restriction

Donor of transferred materialRecipient of transferred materialObservation time after transfer (days)No. of animalsRejection after transfer
B6 (H-2b)B6 (H-2b)125Yes
B6 (H-2b)BALB/c (H-2d)125No/Yes*
B6 (H-2b)NMRI (H-2q)125No
BALB/c (H-2d)BALB/c (H-2d)125Yes
BALB/c (H-2d)B6 (H-2b)129No
BALB/c (H-2d)NMRI (H-2q)125No
NMRI (H-2q)NMRI (H-2q)125Yes
NMRI (H-2q)B6 (H-2b)129No
NMRI (H-2q)BALB/c (H-2d)125No
  • Transfer of immunocompetent cells from donor mice MHC matched or mismatched with the recipient mice that previously received a transplant of ICC xenografts.

  • *

    * Rejection was induced in two of five recipient mice. In one of these two recipient mice, the previously tolerated graft was found to be fibrotic.

  • Four of the animals in these groups were NK cell–depleted during the experiment after repeated intraperitoneal injections of an anti-NK 1.1 monoclonal antibody.