TABLE 1

GAD autoantibody assays

Lab No.Lab-defined sensitivity (%)Lab-defined specificity (%)Area under ROC curve (95% CI)PSensitivity at specificity 90% (AS90 [%])Signal: noise ratioThreshold dilutionAssay typeAntigenLabel
147a78980.97 (0.93–1.00)<0.0001921416RBAHuman GAD67(1–101)/ GAD65(96–585)35S
15088960.97 (0.93–1.00)<0.0001963264RBAHuman GAD65, Full125I
11372980.96 (0.93–1.00)<0.0001923216RBAHuman GAD65, Full35S
11476960.96 (0.93–1.00)<0.0001923764RBAHuman GAD65, Full35S
12378960.96 (0.93–0.99)<0.000186916RBAHuman GAD65, Full35S
11684920.96 (0.92–0.99)<0.0001862364RBAHuman GAD65, Full35S
10974960.95 (0.91–1.00)<0.0001881316RBAHuman GAD65, Full35S
12078960.95 (0.90–1.00)<0.0001932216RBAHuman GAD65, Full35S
12180940.95 (0.90–1.00)<0.0001922364RBAHuman GAD65, Full35S
137781000.94 (0.90–0.99)<0.0001863616RBAHuman GAD65, Full35S
14580900.94 (0.90–0.99)<0.0001841216RBAHuman GAD, 46–586125I
15382920.94 (0.90–0.99)<0.0001883764RBAHuman GAD65, Full35S
10582900.94 (0.89–0.99)<0.0001861116RBAHuman GAD, 46–586125I
13284900.94 (0.89–0.99)<0.0001841516RBAHuman GAD, 46–586125I
15574960.94 (0.89–0.99)<0.00018498RBAHuman GAD65, Full35S
14070980.94 (0.89–0.98)<0.00018044RBAHuman GAD65, Full35S
15280940.94 (0.89–0.98)<0.00018572RBAHuman GAD65, Full35S
12672940.94 (0.88–0.99)<0.000187118RBAHuman GAD65, Full35S
11184980.93 (0.88–0.99)<0.000186616RBAHuman GAD65, Full35S
13384960.93 (0.88–0.99)<0.000190816RBAHuman GAD65, Full3H
11574980.93 (0.88–0.98)<0.00018648RBAHuman GAD65, Full35S
12478900.93 (0.88–0.98)<0.000180864RBAHuman GAD, 46–586125I
15676940.93 (0.87–0.99)<0.000186428RBAHuman GAD65, Full35S
13882960.93 (0.87–0.98)<0.0001861464RBAHuman GAD65, Full35S
14472980.93 (0.87–0.98)<0.000180516RBAHuman GAD65, Full35S
154641000.93 (0.87–0.98)<0.00018588RBAHuman GAD65, Full35S
11876940.92 (0.87–0.98)<0.00018068RBAHuman GAD65, Full35S
14882920.92 (0.87–0.98)<0.0001841116RBAHuman GAD, 46–586125I
119701000.92 (0.86–0.98)<0.0001861616RBAHuman GAD65, Full35S
12976980.92 (0.86–0.98)<0.0001781116RBAHuman GAD65, Full35S
13980960.92 (0.86–0.98)<0.0001881716RBAHuman GAD65, Full35S
14682880.92 (0.86–0.98)<0.00018168RBAHuman GAD65, Full35S
13478940.91 (0.85–0.97)<0.000184118RBAHuman GAD65, Full35S
13682920.91 (0.85–0.97)<0.000183616RBAHuman GAD65, Full35S
12774980.90 (0.84–0.97)<0.000183416RBAHuman GAD65, Full125I
14280840.90 (0.83–0.96)<0.0001762316RBAHuman GAD65, Full35S
12872980.89 (0.83–0.96)<0.00017838RBAHuman GAD65, Full35S
14976840.89 (0.83–0.96)<0.000174118RBAHuman GAD65, Full35S
14176900.89 (0.82–0.95)<0.000178616RBAHuman GAD65, Full35S
11074940.86 (0.79–0.94)<0.00017468RBAHuman GAD65, Full35S
147b76840.86 (0.79–0.94)<0.000162916RBAHuman GAD, 46–586125I
135581000.86 (0.78–0.94)<0.00017438RBAHuman GAD65, Full35S
13166940.85 (0.78–0.93)<0.00016874RBAHuman GAD65, Full35S
11260960.85 (0.77–0.93)<0.00017384IFMAHuman GAD65, FullEuropium
11780800.85 (0.77–0.93)<0.000174916RBAHuman GAD65, Full35S
15172920.82 (0.73–0.91)<0.000176616ELISAHuman GAD65, FullHRP