TABLE 2

IA-2 autoantibody assays

Lab No.Lab-defined sensitivity (%)Lab-defined specificity (%)Area under ROC curve (95% CI)PSensitivity at specificity 90% (AS90 [%])Signal: noise ratioThreshold dilutionAssay typeAntigenLabel
11562980.90 (0.84–0.96)<0.0001743764RBAhu IA-2 ic35S
150581000.86 (0.79–0.94)<0.0001721364RBAhu IA-2 ic125I
12856980.84 (0.76–0.94)<0.0001621516RBAhu IA-2 ic35S
133a521000.84 (0.75–0.92)<0.0001649064RBAhu IA-2 bdc35S
144541000.83 (0.75–0.91)<0.0001586464RBAhu IA-2 ic35S
132581000.83 (0.74–0.91)<0.0001662264RBAhu IA-2 ic125I
11360920.83 (0.74–0.91)<0.00016814116RBAhu IA-2 ic35S
136581000.82 (0.74–0.91)<0.00016898RBAhu IA-2 ic35S
156571000.82 (0.73–0.91)<0.00016764RBAhu IA-2 ic35S
13558940.82 (0.73–0.90)<0.0001622416RBAhu IA-2 bdc/ic35S
10952980.81 (0.72–0.90)<0.0001661764RBAFull length IA-235S
145581000.81 (0.71–0.90)<0.000172202RBAhu IA-2 ic125I
124581000.81 (0.71–0.90)<0.0001681216RBAhu IA-2 ic125I
14772600.80 (0.71–0.88)<0.00015648RBAhu ICA512, 1–97935S
10558980.80 (0.70–0.89)<0.000168114RBAhu IA-2 ic125I
13860980.79 (0.69–0.89)<0.0001687464RBAhu IA-2 ic35S
15260940.79 (0.69–0.88)<0.000162218RBAhu IA-2 ic35S
126561000.79 (0.69–0.88)<0.0001615664RBAhu IA-2 ic35S
111561000.78 (0.69–0.88)<0.00016210664RBAhu IA-2 ic35S
155501000.78 (0.68–0.87)<0.0001581164RBAFull length IA-235S
137541000.77 (0.68–0.87)<0.0001581388RBAhu IA-2 ic35S
140561000.77 (0.67–0.87)<0.00015610164RBAhu IA-2 ic35S
129541000.77 (0.67–0.87)<0.0001584664RBAhu IA-2 ic35S
133b571000.76 (0.66–0.86)<0.000159No standard curveRBAhu IA-2 ic35S
123541000.76 (0.66–0.86)<0.00016211164RBAhu IA-2 ic35S
13188280.75 (0.66–0.85)<0.000152218RBAhu IA-2 ic35S
14954920.75 (0.65–0.85)<0.0001507264RBAhu IA-2 bdc35S
148581000.75 (0.65–0.85)<0.00015810564RBAhu IA-2 ic35S
13456980.75 (0.65–0.85)<0.0001582516RBAhu IA-2 ic35S
11854960.75 (0.65–0.85)<0.0001544716RBAhu IA-2 bdc35S
121581000.74 (0.64–0.85)<0.00015812064RBAhu IA-2 ic35S
14652980.73 (0.63–0.84)<0.0001601764RBAhu IA-2 bdc35S
10750940.73 (0.63–0.83)<0.000152358ELISAhu IA-2 icHRP
153581000.73 (0.62–0.83)<0.0001596264RBAhu IA-2 ic35S
11758740.72 (0.62–0.82)<0.0001544464RBAhu IA-2 bdc35S
15154900.71 (0.60–0.83)<0.000154274ELISAhu IA-2 icHRP
139581000.71 (0.60–0.82)<0.0001598564RBAhu IA-2 ic35S
11658980.71 (0.59–0.82)<0.00015811464RBAhu IA-2 ic35S
12058900.70 (0.59–0.81)<0.00015812864RBAhu IA-2 ic35S
14148980.70 (0.59–0.80)0.001503964RBAhu IA-2 bdc35S
14250960.70 (0.58–0.81)0.0015611864RBAhu IA-2 bdc3H
114581000.68 (0.56–0.79)0.0035813264RBAhu IA-2 ic35S
119501000.65 (0.54–0.77)<0.0001522716RBAhu IA-2 bdc35S
11052940.65 (0.53–0.77)0.011543164RBAhu IA-2 bdc35S