TABLE 3

Insulin autoantibody assays

Lab no.Lab-defined sensitivity (%)Lab-defined specificity (%)Area under ROC curve (95% CI)PSensitivity at specificity 90% (AS90 [%])Assay typeAntigenLabel
116361000.80 (0.71–0.90)<0.000166RBAHuman insulin125I
120321000.77 (0.68–0.86)<0.000152RBAHuman insulin125I
133141000.77 (0.68–0.86)<0.000147RBAHuman insulin125I
15334980.77 (0.68–0.87)<0.000164RBAHuman insulin125I
12130980.75 (0.66–0.85)<0.000147RBAHuman insulin125I
126161000.75 (0.65–0.88)<0.000151RBAHuman insulin125I
15661000.73 (0.62–0.83)<0.000156RBAHuman insulin125I
14842980.72 (0.62–0.82)<0.000150RBAHuman insulin125I
11810980.70 (0.60–0.81)<0.000136RBAHuman insulin125I
13841000.63 (0.58–0.79)0.00232RBAHuman insulin125I
140141000.68 (0.57–0.78)0.00340RBAHuman insulin125I
115161000.67 (0.57–0.78)0.00342RBAHuman insulin125I
113121000.66 (0.55–0.77)0.00630RBAHuman insulin125I
12330900.65 (0.54–0.76)0.01226RBAHuman insulin125I
1378960.64 (0.53–0.75)0.01429RBAHuman insulin125I
1494980.62 (0.51–0.73)0.03321RBAHuman insulin125I
14581000.62 (0.50–0.73)0.04438RBAHuman insulin125I
114141000.59 (0.48–0.70)0.12126RBAHuman insulin125I
11716980.58 (0.47–0.70)0.15525RBAHuman insulin125I
13281000.58 (0.44–0.67)0.32419RBAHuman insulin125I
13561000.55 (0.43–0.66)0.40419RBAHuman insulin125I
13620940.52 (0.40–0.63)0.74621RBAHuman insulin125I
10561000.32 (0.21–0.42)0.00213RBAHuman insulin125I