TABLE 1

The effect of DC-41-33 on hormonal responses in the presence of SST, in batch-incubated islets

SST (nmol/l)DC-41-33 (μmol/l)Insulin (pmol · islet−1 · h−1)Glucagon (pg · islet−1 · h−1)
000.17 ± 0.0130.8 ± 6.2
020.22 ± 0.02*158.7 ± 11.9*
1000.15 ± 0.0111.0 ± 1.1
1020.24 ± 0.02*138.7 ± 11.7*
10000.14 ± 0.0113.4 ± 2.5
10020.20 ± 0.02*68.1 ± 9.4*
1,00000.12 ± 0.0113.3 ± 1.9
1,00020.17 ± 0.03*25.2 ± 5.1
  • Data were obtained from the batch incubations shown in Fig. 2 and are presented as means ± SE of three experiments (three to five observations per experiment).

  • *

    * P < 0.001 vs. without DC-41-33;

  • P < 0.001 vs. 0 nmol/l SST + DC-41-33.