TABLE 2

The effect of DC-41-33 on hormonal release in perfused pancreas

MinDC-41-33 (μmol/l)3.3 mmol/l glucose
5.5 mmol/l glucose
20% of the standard Ca2+ 3.3 mmol/l glucose
InsulinGlucagonInsulinGlucagonInsulinGlucagon
0–4014.4 ± 2.99.6 ± 2.230.6 ± 5.04.7 ± 1.28.1 ± 1.58.2 ± 1.6
0–419.8 ± 1.316.9 ± 2.224.7 ± 8.37.0 ± 1.23.7 ± 1.46.3 ± 1.4
4–20038.2 ± 6.233.3 ± 7.589.0 ± 14.619.1 ± 5.512.7 ± 2.328.1 ± 8.2
4–20138.2 ± 7.291.1 ± 20.2*119.8 ± 36.347.0 ± 6.114.1 ± 3.632.8 ± 7.4
0–20052.6 ± 8.743.0 ± 9.6119.7 ± 18.823.4 ± 6.420.8 ± 3.336.3 ± 9.5
0–20147.9 ± 8.4108.0 ± 22.2*144.5 ± 44.454.1 ± 7.217.7 ± 4.739.1 ± 8.8
  • Data were obtained from the perfusion experiments shown in Figs. 46 and represent the amounts of insulin (pmol) and glucagon (ng) released during the 20-min stimulation period. Arginine (20 mmol/l) was used as the stimulus. The hormone amount is calculated as the area under the curve, using the secretion rate at min 0 as the basal value.

  • *

    * P < 0.02,

  • P < 0.005, and

  • P < 0.01 vs. without DC-41-33.