TABLE 2

HG-induced changes in gene expression in THP-1 cells

Gene name (accession nos.)(Fold change relative to NG)
Adhesion
 CAD-11 (L34056)↑ (2.9)
 K-cadherin (D31784)↑ (1.47)
 P-cadherin (X63629)↑ (2.21)
 R-cadherin (L34059)↑ (2.49)
 B-CAM (X80026)↑ (2.52)
 PECAM-1 (M28526)↑ (3.60)
 MCAM (M28882)↑ (3.49)
Angiogenic
 Endothelin R type B (L06623)↑ (3.8)
 VEGF-B (U43368)↑ (5.9)
 VEGF-D (D89630)
Cell surface proteins
 SLAM (U33017)↑ (3.7)
 Endoglin (X72012)↑ (1.6)
 CD8α (M12828)↑ (2.1)
 CD-34 (M81104)
 DNAM-1 (U56102)↑ (3.57)
Chemokines
 MCP-1 (S69738)↑ (2.0)
 HCC-4 (U91746)↑ (1.8)
 MCP-3 (X71087)↑ (1.5)
 IP-10 (X02530)↑ (1.9)
 TARC (D43767)↑ (4.48)
 MIP-3β (AB000887)↑ (3.39)
Chemokine receptors
 CCR-2B (U03905)↑ (7.7)
 CCR-4 (X85740)↑ (3.0)
 CCR-5 (U57840)↑ (2.5)
 CCR-7 (L31581)
Cytokines
 IGF-1 (X56773)
 GM-CSF (M10663)
 M-CSF-1 (M64592)
 MSP (L11924)
Cytokine receptors
 IFN-α/β Rβ (U29584)
 PDGF Rβ (M21616)
Ephrin Receptors
 Eph-A2 (M59371)↑ (3.4)
 Eph-B6 (D83492)
FGF family
 FGF-7 (M60828)
 FGF-9 (D14838)
 FHF-1 (U66197)
 FHF-4 (U66200)↑ (7.1)
Integrin
 β2-Integrin (M15395)↑ (4.4)
 α9-Integrin (L24158)↑ (1.9)
Interleukin
 IL-1α (M28983)↑ (3.3)
 IL-1β (M15330)↑ (14)
Int Receptors.
 IL-1RII (U64094)↑ (1.7)
Orphan Receptors
 GPR24 (U71092)↑ (3.1)
 GPR31 (U65402)↑ (4.6)
TNF Superfamily
 TNF-α (M10988)↑ (1.87)
 TNF-β (D12614)↑ (2.2)
 CD30 (M83554)↑ (2.3)
NO metabolism
 iNOS (L09210)↑ (2.25)
Protease
 MMP-13 (X75308)↑ (2.8)
 TIMP-2 (M32304)↑ (4.6)
 TIMP-4 (U76456)↑ (2.9)
TGF β Superfamily
 BMP-7 (NM_001719)↑ (4.6)
 4-1BB (U03397)↑ (4.6)
 Apo-2 ligand (U57059)
 CD27L (L08096)↑ (3.3)
Neurotrophic Factor
 GDNF (L19063)
  • ↑, increase in expression; ↓, decrease in expression.