TABLE 3

Association of SHP G171A genotype with BMI in all cohorts stratified by sex and in all three cohorts combined using Z scores from log-transformed data

GenotypePopulation control subjects
Young-onset type 2 diabetic subjects
Young-onset type 2 diabetic parents
Combined
Fathers (n = 457)Mothers (28 weeks pregnant) (n = 468)Men (n = 201)Women (n = 147)Fathers (n = 137)Mothers (n = 135)Z scores (n = 1,545)
G/G26.3 (17.0–40.0)26.9 (20.1–47.1)30.1 (18.8–44.6)33.2 (18.1–50.5)26.8 (16.3–40.5)28.3 (17.3–45.0)−0.054
(n = 391)(n = 404)(n = 169)(n = 126)(n = 119)(n = 114)(n = 1323)
G/A26.5 (20.2–34.9)27.0 (20.9–41.1)30.3 (19.7–46.4)34.0 (21.1–59.6)27.1 (21.3–41.2)26.4 (17.4–40.9)0.004
(n = 64)(n = 62)(n = 30)(n = 20)(n = 16)(n = 21)(n = 213)
A/A31.0 (26.3–35.7)29.4 (25.9–32.9)34.2 (32.9–35.5)36.030.4 (28.6–32.2)0.672
(n = 2)(n = 2)(n = 2)(n = 1)(n = 2)(n = 0)(n = 9)
P value
 A/G vs. G/G0.610.720.890.560.750.060.68
 A/A vs. G/*0.250.520.230.120.02
  • Data are median (range).