TABLE 1

Variant sequences in PrRP and GPR10 found in 94 unrelated subjects with severe early-onset obesity

GenePolymorphism (nucleotide)Coding change (amino acid)Type of changeAllele frequency
GPR10G-62ANoncoding23%
G-37CNoncoding1%
G285AT95TSilent8%
C648AG216GSilent1%
A747CS249SSilent2%
G847AV283IConservative1%
C914TP305LNonconservative7%
C1036TL346LSilent1%
PrRPG-83ANoncoding1%
Cintron*268TNoncoding1%
G183AG61GSilent1%
C+8ANoncoding6%
  • “-number,” number of base pairs upstream of the start codon at which the polymorphism occurs; “intron

  • *

    * number,” number of bases along the intron at which the polymorphism occurs; “+number,” number of base pairs downstream of the stop codon at which the polymorphism occurs.