TABLE 2

Relationship between genotype at G-62A and C914T (within GPR10) and obesity- and cardiovascular-related phenotypes in a U.K. Caucasian population

Phenotype
P value, adjusted for
G/G (wild type)G/AA/AAge, sexAge, sex, BMI
G-62A
n (observations)581 (1,033)382 (695)63 (114)
BMI (kg/m2)26.46 ± 0.1926.25 ± 0.2226.63 ± 0.410.778
Diastolic blood pressure (mmHg)77.28 ± 0.3878.27 ± 0.4679.76 ± 1.250.169
Systolic blood pressure (mmHg)127.09 ± 0.59128.48 ± 0.70133.80 ± 1.980.017
Phenotype
Significance, adjusted for
C/C (wild type)C/T and T/TAge, sexAge, sex, BMI
C914T
n (observations)1,004 (1,807)80 (142)
BMI (kg/m2)26.39 ± 0.1425.85 ± 0.400.245
Diastolic blood pressure (mmHg)78.20 ± 0.2974.90 ± 0.900.008
Systolic blood pressure (mmHg)128.55 ± 0.46123.95 ± 1.330.023
  • Data are adjusted arithmetic means ± SD. n is the total number of individuals who were genotyped. The number of observations refers to the measures of phenotype, which in most cases were recorded at baseline and then again at follow-up.