TABLE 1

Metabolic parameters during basal (overnight fasted) and hyperinsulinemic-euglycemic clamp periods in the wild-type, fatless, and fat-transplanted fatless mice with or without 3 weeks of rosiglitazone treatment (Rosi-treated)

nBody weight (g)Basal period
Clamp period
Plasma glucose (mmol/l)Plasma insulin (pmol/l)Plasma glucose (mmol/l)Plasma insulin (pmol/l)
Wild-type624 ± 17.2 ± 0.783 ± 186.5 ± 0.6615 ± 41
Wild-type Rosi-treated423 ± 17.1 ± 0.389 ± 147.4 ± 0.9690 ± 40
Fatless523 ± 117.1 ± 2.1*72 ± 188.6 ± 1.7715 ± 57
Fatless Rosi-treated623 ± 113.7 ± 1.7*118 ± 299.0 ± 1.1643 ± 34
Fat-transplanted fatless723 ± 19.8 ± 1.0111 ± 256.8 ± 0.4684 ± 39
Fat-transplanted fatless Rosi-treated1122 ± 110.4 ± 1.1124 ± 346.8 ± 0.5627 ± 20
  • *

    * P < 0.05 vs. wild-type mice by Duncan’s multiple range test;

  • P < 0.05 vs. fatless mice by Duncan’s multiple range test.