TABLE 2

Pharmacological properties of isoprenaline, β-adrenoceptor agonists, forskolin, and dcAMP in human subcutaneous adipocytes from subjects with or without HSL-S

Maximal glycerol release*pD2
Basal
 L group1.10 ± 0.19
 L + S group0.80 ± 0.13
Isoprenaline
 L group3.21 ± 0.55
 L + S group1.95 ± 0.29
Noradrenaline
 L group2.46 ± 0.406.97 ± 0.34
 L + S group1.36 ± 0.277.63 ± 0.15
Forskolin
 L group3.29 ± 0.52
 L + S group2.04 ± 0.30
dcAMP
 L group3.19 ± 0.46
 L + S group2.03 ± 0.32
  • Data are means ± SE. n = 7.

  • *

    * Lipolysis rates (μmol · 2 h–1 · g–1 triglycerides) at the maximal effective agonist concentration with the basal value subtracted.

  • pD2 = −log EC50 (effective agonist concentration causing 50% of maximal effect);

  • P < 0.05: (1 band) vs. (2 bands) group.