TABLE 1

Survival of neonatal porcine islet grafts in B6 MHC class II-deficient mice

Transfer of CD45.1+ CD4 T cellsnGraft survival post-CD4 T-cell transfer (days)
1) None11>100 × 11
2) 107 CD4 T-cells day −15>100 × 5
3) 107 CD4 T-cells postfunction3>30 × 3
  • Streptozotocin-induced diabetic C2D mice were transplanted with 2,000 NPIs. Control C2D recipients were otherwise untreated (group 1). In one group, C2D recipient mice received 107 B6.CD45.1+ CD4 T-cells either on day −1 relative to transplantation (group 2) or 1–2 weeks after normal blood glucose has been achieved (group 3).