TABLE 2

Characteristics of NOD mice exposed to H-AGE and L-AGE diets

H-AGE diet
L-AGE diet
BaselineEndBaselineEnd
Body weight (g)15.2 ± 123.5 ± 1.214.5 ± 125 ± 2.2
Fasting blood glucose (mg/dl)55 ± 18195 ± 4860 ± 11205 ± 61
Serum creatinine (mg/dl)0.61 ± 0.20.68 ± 0.10.62 ± 0.20.60 ± 0.1
Albumin/creatinine excretion (mg/mg)1.5 ± 0.18.3 ± 0.51.2 ± 0.11.7 ± 0.2
AGE/creatinine excretion (units/mg)1.4 ± 0.13.8 ± 0.91.7 ± 0.12.1 ± 0.3
  • Data are means ± SD.

  • *

    * Refers to AIN-93G, as defined in Table 1 (ref. 36);

  • P < 0.002;

  • P < 0.025.