TABLE 6

Regression analysis of factors affecting regional protein dynamics (phenylalanine model) and leucine kinetics

ΔInsulin
ΔLeucine
ΔInsulin * ΔLeucine
Regression (r2)
β ± SEMP valueβ ± SEMP valueβ ± SEMP
Phenylalanine model
 PB leg−0.023 ± 0.0070.004NSNS0.20
 PB splanchnicNS−0.007 ± 0.0030.028NS0.11
 PS leg0.03 ± 0.010.0080.007 ± −0.0010.000110.080.62
 PS splanchnicNS0.05 ± 0.0050.0001NS0.76
 Net bal leg0.068 ± 0.0110.00010.011 ± 0.0020.0001−0.0002 ± 0.000050.0120.77
 Net bal splanchnicNS0.073 ± 0.0050.001NS0.85
Leucine model
 Leu N flux leg−0.236 ± 0.0940.0170.017 ± 0.1070.0001NS0.77
 Leu N flux splanchnicNS0.119 ± 0.0190.0001NS0.51
 KIC to Leu leg−0.212 ± 0.0730.0070.102 ± 0.0080.0001NS0.83
 KIC to Leu splanchnic0.610.102 ± 0.0210.00010.0220.79
 Net bal leg0.228 ± 0.0410.00010.067 ± 0.0040.0001NS0.90
 Net bal splanchnic0.346 ± 0.0870.00040.139 ± 0.0090.0001NS0.89
  • The results represent the significant effects of changes (Δ) in insulin, leucine, and interaction of leucine and insulin (ΔInsulin * ΔLeucine) on changes in PB, PS, and net balance (Net bal) in leg and splanchnic beds. Similar data are provided for leucine (Leu), nitrogen (N) flux, KIC, and leucine transamination and net balance.