TABLE 1

Parameters of hepatic glucose metabolism under basal conditions in conscious control and liver-specific PEPCK knockout mice

ControlKnockout
G6P (nmol/g)221 ± 1823 ± 3
UDP-glucose (nmol/g)177 ± 15303 ± 24*
Hepatic [3H]UDP-glucose SA/plasma [3H]glucose SA0.095 ± 0.0040.600 ± 0.087
G6Pase Vmax (nmol/ · min−1 · mg−1 protein)548 ± 22369 ± 22
Glucokinase activity (nmol · min−1 · mg−1 protein)22.9 ± 1.312.3 ± 0.8
  • Data are means ± SE. [3-3H]glucose was infused for 220 and 120 min, respectively. Male mice ages 7–8 months were fasted for 26 h before infusions.

  • *

    * P < 0.01;

  • P < 0.001 versus control values at each condition (n = 4–7).