TABLE 1

Baseline characteristics of overall cohort and three age-at-onset subgroups

OverallPrepubertyPubertyPostpuberty
n2431843524
Age at onset (years)8.8 ± 4.8 (0.5, 31.5)6.8 ± 2.9 (0.5, 12.0)12.8 ± 1.0 (11.1, 14.3)18.5 ± 4.3 (14.0, 31.5)
Age at biopsy (years)16.8 ± 6.0 (9.5, 38.0)14.9 ± 4.0 (9.5, 29.1)18.6 ± 3.7 (13.0, 32.3)28.9 ± 6.3 (16.5, 38.0)
Diabetes duration (years)8.0 ± 4.2 (1.8, 20.3)8.1 ± 4.0 (2.0, 19.8)5.8 ± 3.7 (1.8, 19.1)10.4 ± 5.1 (2.1, 20.3)
HbA1c (%)8.7 ± 1.5 (5.3, 13.9)8.7 ± 1.4 (5.7, 13.5)9.0 ± 1.8 (6.2, 13.9)8.1 ± 1.6 (5.3, 11.9)
Systolic BP (mmHg)113.5 ± 11.1 (85.5, 145.0)112.2 ± 10.6 (85.5, 140.0)113.2 ± 10.1 (92.0, 135.0)124.2 ± 11.0 (99.0, 145.0)
Diastolic BP (mmHg)62.8 ± 8.9 (44.5, 89.5)61.7 ± 7.9 (45.0, 82.0)61.4 ± 8.3 (44.5, 75.5)74.6 ± 8.7 (59.0, 89.5)
Vv(Mes/glom)0.22 ± .05 (0.13, 0.42)0.22 ± .04 (0.14, 0.41)0.21 ± 0.05 (0.13, 0.34)0.25 ± 0.06 (0.15, 0.42)
GBM (nm)428 ± 77 (266, 715)425 ± 76 (266, 692)427 ± 60 (314, 575)452 ± 102 (330, 715)
Sv(PGBM/glom)0.14 ± 0.02 (0.09, 0.20)0.14 ± 0.02 (0.09, 0.19)0.14 ± 0.02 (0.09, 0.20)0.13 ± 0.03 (0.09, 0.18)
  • Data are means ± SD (min, max). BP, blood pressure.