TABLE 2

Metabolic characteristics of nondiabetic subjects by Pro12Ala genotypes

Pro/ProPro/Ala + Ala/AlaP
n (f/m)203 (84/119)38 (15/23)
Age (years)28 ± 125 ± 10.42
Fat (%)33 ± 130 ± 20.25
Fasting plasma glucose (mg/dl)92 ± 189 ± 10.18
2-h plasma glucose (mg/dl)128 ± 2118 ± 50.12
Fasting insulin (μU/ml)42 ± 131 ± 30.01
2-h insulin (μU/ml)226 ± 12173 ± 260.08
Glucose disposal
 Low-dose insulin clamp (mg · kg EMBS−1 · min−1)2.49 ± 0.12.88 ± 0.10.26
 High-dose insulin clamp (mg · kg EMBS−1 · min−1)8.4 ± 0.19.5 ± 0.30.05
Basal glucose output (mg · kg EMBS−1 · min−1)1.91 ± 0.011.94 ± 0.030.18
Hepatic insulin sensitivity (suppressed endogenous glucose output) (mg · kg EMBS−1 · min−1)0.30 ± 0.020.18 ± 0.030.03
  • Data are means ± SE. P values in bold are significant. EMBS, estimated metabolic body size.