TABLE 3

Metabolic characteristics of nondiabetic subjects by the promoter SNP C-2821T genotypes

C/CC/TT/TP
n (f/m)75 (22/53)126 (61/65)40 (16/24)
Age (years)28 ± 127 ± 126 ± 10.5
Fat (%)32 ± 133 ± 132 ± 20.7
Fasting plasma glucose (mg/dl)92 ± 192 ± 193 ± 10.4
2-h plasma glucose (mg/dl)129 ± 4124 ± 3132 ± 60.03
Fasting insulin (μU/ml)42 ± 240 ± 139 ± 30.1
2-h insulin (μU/ml)239 ± 23203 ± 13221 ± 310.1
Glucose disposal
 Low-dose insulin clamp (mg · kg EMBS−1 · min−1)2.4 ± 0.12.5 ± 0.12.6 ± 0.10.7
 High-dose insulin clamp (mg · kg EMBS−1 · min−1)8.1 ± 0.28.8 ± 0.28.9 ± 0.40.04
Basal glucose output (mg · kg EMBS−1 · min−1)1.91 ± 0.021.91 ± 0.021.90 ± 0.030.83
Hepatic insulin sensitivity (suppressed endogenous glucose output) (mg · kg EMBS−1 · min−1)0.32 ± 0.030.27 ± 0.080.21 ± 0.030.05
  • Data are means ± SE. P values in bold are significant. EMBS, estimated metabolic body size.