TNF-α promoter polymorphism (G-308A) as a predictor for the development of type 2 diabetes by the study group (logistic regression analysis)
| Regression coefficient | P | OR | 95% CI | |
|---|---|---|---|---|
| Model 1 (univariate) | ||||
| TNF-α −308A allele | ||||
| All participants | 0.587 | 0.034 | 1.80 | 1.05–3.09 |
| Control group | 0.111 | 0.751 | 1.12 | 0.56–2.22 |
| Intervention group | 1.439 | 0.003 | 4.22 | 1.62–11.0 |
| Model 2 (multivariate) | ||||
| Intervention group | ||||
| TNF-α −308A allele | 1.465 | 0.006 | 4.39 | 1.53–12.3 |
| Weight at baseline | 0.047 | 0.005 | 1.05 | 1.01–1.08 |
| Weight change | 0.181 | 0.001 | 1.21 | 1.08–1.35 |
TNF-α genotypes were encoded as 0 = the G-308G genotype and 1 = the −308A allele. Weight change was calculated as (weight [kg] 3 years − weight [kg] baseline)/weight (kg) baseline × 100%. If diabetes was diagnosed before the 3-year examination, the weight at the visit when diabetes was diagnosed was used in statistical analyses.