TABLE 1

Patient characteristics

Nondiabetic control subjectsSubjects with IGTType 2 Diabetic patients
Age (years)44 ± 2 (18)43 ± 3 (6)50 ± 3 (10)
BMI27 ± 1 (18)34 ± 2 (6)32 ± 2 (10)
P < 0.004P < 0.03
Fasting plasma glucose (mmol/l)5.1 ± 0.2 (18)6.2 ± 0.1 (6)8.7 ± 1.4 (10)
P < 0.001
Serum insulin (pmol)111 ± 16 (17)346 ± 124 (6)235 ± 43 (10)
P < 0.004P < 0.05
Serum C-peptide (ng/ml)1.46 ± 0.17 (17)3.63 ± 0.97 (6)2.63 ± 0.34 (10)
P < 0.001P < 0.03
HbA1c (%)4.79 ± 0.13 (18)5.42 ± 0.25 (6)7.00 ± 0.71 (10)
P < 0.0003
Triglycerides (mg/dl)141 ± 16 (18)209 ± 39 (6)209 ± 36 (10)
Systolic blood pressure (mmHg)127 ± 3 (18)136 ± 76 (6)139 ± 6 (10)
Diastolic blood pressure (mmHg)76 ± 2 (18)82 ± 3 (6)85 ± 2 (10)
P < 0.02
Serum free fatty acids (mmol)0.44 ± 0.03 (17)0.52 ± 0.08 (4)0.51 ± 0.04 (10)
Glucose disposal rate (mg · kg−1 · min−1)11.60 ± 1.11 (18)5.92 ± 1.01 (6)4.90 ± 0.74 (10)
P < 0.004P < 0.0001
  • Data are means ± SE (number of determinations). P values versus normal nondiabetic control subjects, by ANOVA.