TABLE 1

Body weight and food consumption of STZ diabetic and control rats with high-dose thiamine and benfotiamine therapy

Study groupBody weight at baseline (g)Body weight at 24 weeks (g)Mean study food consumption (g/day)
Thiamine dosing
  C278 ± 13712 ± 93*36
  CT70265 ± 5689 ± 32*32
  DC268 ± 12351 ± 4147§
  CT7266 ± 15317 ± 3032
  CT70259 ± 15398 ± 10236
Benfotiamine dosing
  C235 ± 9607 ± 32*30
  CB70240 ± 11675 ± 66*30
  DC243 ± 15318 ± 4954§
  DB7241 ± 8380 ± 5162§
  DB70251 ± 8334 ± 5646§#
  • *

    * P < 0.001,

  • P < 0.01 vs. baseline control;

  • P < 0.001 vs. 24-week normal control;

  • §

    § P < 0.001 vs. normal control;

  • P < 0.001,

  • P < 0.01,

  • #

    # P < 0.05 vs. diabetic control.