TABLE 1

Body weight and basal values of different plasma parameters in wild-type (Wt) and transgenic (Tg) mice with overexpression of HSL in β-cells

7–8 Weeks of age
16 weeks of age (3 weeks of high-fat diet)
22 weeks of age (9 weeks of high-fat diet)
Female
Male
Female
Male
Female
Male
WtTgWtTgWtTgWtTgWtTgWtTg
n1213161665876585
Body weight (g)18.2 ± 0.418.2 ± 0.423.0 ± 0.723.6 ± 0.525.5 ± 1.627.8 ± 1.637.6 ± 1.236.4 ± 231.0 ± 2.238.5 ± 2.1*37.6 ± 1.236.4 ± 2.0
Insulin (pmol/l)72 ± 1375 ± 10157 ± 14237 ± 22333 ± 62259 ± 69997 ± 57510 ± 74335 ± 69219 ± 654540 ± 11203146 ± 1323
Glucagon (pmol/l)39 ± 852 ± 842 ± 852 ± 6102 ± 1190 ± 1172 ± 1070 ± 498 ± 1282 ± 1289 ± 576 ± 5
Glucose (mmol/l)6.4 ± 0.46.6 ± 0.46.7 ± 0.25.8 ± 0.27.2 ± 0.56.6 ± 0.510.3 ± 0.39.7 ± 0.76.4 ± 0.57.8 ± 0.611.4 ± 0.910.9 ± 1.6
FFA (mmol/l)1.09 ± 0.050.88 ± 0.041.28 ± 0.041.18 ± 0.091.13 ± 0.061.06 ± 0.091.02 ± 0.041.34 ± 0.090.64 ± 0.050.75 ± 0.030.69 ± 0.040.75 ± 0.06
Leptin (nmol/l)1.8 ± 0.11.7 ± 0.11.6 ± 0.11.5 ± 0.120 ± 511 ± 327 ± 433 ± 725 ± 528 ± 741 ± 236 ± 6
  • Data are means ± SE. Blood samples were taken at 8, 16, 22, and 26 weeks of age from mice in each feeding group. The table shows data from diet-fed mice at 8 weeks of age and after feeding high-fat diet for 3 and 9 weeks, respectively. Differences between individual data were compared with unpaired, two-tailed t-test.

  • *

    * P<0.05,

  • P<0.01.