TABLE 1

Plasma pancreatic polypeptide, glucagon, growth hormone, and cortisol concentrations during hyperinsulinemic-stepped hypoglycemic (85, 75, 65, 55, and 45 mg/dl) clamps on day 2 after saline or cortisol infusions on day 1

Time (min)Pancreatic polypeptide (pg/ml)
Glucagon (pg/ml)
Growth hormone (ng/ml)
Cortisol (μg/dl)
After salineAfter cortisolAfter salineAfter cortisolAfter salineAfter cortisolAfter salineAfter cortisol
−3081 ± 1271 ± 1077 ± 575 ± 93.6 ± 1.63.2 ± 1.316.5 ± 2.011.3 ± 1.5
−1580 ± 1178 ± 1676 ± 576 ± 63.9 ± 1.82.7 ± 1.114.8 ± 1.89.3 ± 1.2
062 ± 768 ± 1374 ± 570 ± 63.4 ± 1.52.5 ± 0.814.0 ± 2.18.8 ± 1.1
3060 ± 863 ± 866 ± 564 ± 64.7 ± 1.61.1 ± 0.313.0 ± 2.08.3 ± 1.0
6058 ± 754 ± 661 ± 558 ± 62.9 ± 0.92.0 ± 1.312.7 ± 2.18.5 ± 0.9
9067 ± 1359 ± 1062 ± 461 ± 61.0 ± 0.31.8 ± 1.211.4 ± 2.08.0 ± 1.0
12058 ± 954 ± 762 ± 462 ± 81.0 ± 0.41.2 ± 0.510.7 ± 1.47.2 ± 0.9
15080 ± 1456 ± 769 ± 672 ± 81.4 ± 0.61.0 ± 0.310.9 ± 1.97.8 ± 1.1
180217 ± 70104 ± 2177 ± 1081 ± 126.0 ± 0.44.0 ± 1.711.3 ± 1.19.6 ± 1.4
210240 ± 59253 ± 9597 ± 1192 ± 1312.1 ± 3.36.5 ± 1.914.8 ± 1.410.3 ± 1.3
240398 ± 79267 ± 50103 ± 11112 ± 1817.8 ± 3.811.2 ± 2.117.8 ± 1.014.7 ± 1.9
270518 ± 63392 ± 68112 ± 1398 ± 1019.8 ± 4.516.2 ± 3.521.4 ± 1.517.2 ± 1.8
300467 ± 56398 ± 53103 ± 13121 ± 2220.1 ± 3.218.8 ± 4.025.7 ± 2.021.2 ± 2.0
  • Data are means ± SE. *To convert pancreatic polypeptide to pmol/l multiply by 0.239, glucagon to pmol/l multiply by 0.287, growth hormone to pmol/l multiply by 44.15, and cortisol to nmol/l multiply by 27.59.