TABLE 1

Binding, internalization, and degradation of insulin and insulin analogs in rat myoblasts

Binding (fmol/2 × 105 cells)Internalization (cpm × 102)Degradation (%)
Human insulin2.8 ± 0.062,200 ± 2006.3 ± 0.5
HMR 19642.2 ± 0.11,600 ± 3003.0 ± 0.4
AspB104.2 ± 0.05*3,400 ± 400*2.6 ± 0.7
HMR 11534.4 ± 0.01*5,500 ± 1,100*5.0 ± 0.3
  • Data are means ± SE taken from 4–5 separate experiments. Binding, internalization, and degradation of insulin and insulin analogs was determined as described in research design and methods.

  • *

    * Significantly different from human insulin and HMR 1964 at P < 0.05;

  • significantly different from HMR 1964 and AspB10 at P < 0.05.