TABLE 1

Exacerbation of STZ-induced diabetes in TRAIL−/− mice*

MiceIncidence (%)Day of onset (mean ± SEM)Range of urine glucose (mg/dl)§Degree of insulitis (mean ± SEM)
TRAIL+/+7/13 (53.8)20.3 ± 7.4500–1,0000.9 ± 0.15
TRAIL−/−12/13 (92.3)10 ± 4.31,000–2,0003.2 ± 0.18
  • *

    * Data are pooled from three independent experiments.

  • The cumulative disease incidence. The difference between the two groups is statistically significant (P < 0.001).

  • The difference in day of onset between the two groups is statistically significant (P < 0.05).

  • §

    § Range of urine glucose levels of diabetic mice 50 days after the first STZ injection. (The urine glucose levels of nondiabetic mice were <100 mg/dl.) The difference between the two groups is statistically significant (P < 0.0001).

  • Mean insulitis grades of diabetic mice. A total of 50 islets were scored for each group. The difference between the two groups is statistically significant (P < 0.0001).