TABLE 1

Subject characteristics and measures during whole-body insulin-stimulated glucose uptake in young healthy subjects, age matched healthy subjects, and patients with type 2 diabetes

Young healthy subjectsAge-matched healthy subjectsDiabetic subject
Age (years)23 ± 150 ± 2*42 ± 3*
Body mass (kg)79.2 ± 2.484.1 ± 3.393.6 ± 10.2
BMI24.0 ± 1.027.4 ± 1.230.1 ± 2.2*
Percent body fat12.3 ± 325.5 ± 4.8*31.0 ± 2.9*
HbA1c (%)4.5 ± 0.15.0 ± 4.88.1 ± 0.7
Fasting blood glucose (mmol/l)4.2 ± 0.14.4 ± 0.18.6 ± 1.8
Fasting plasma insulin (pmol/l)40.5 ± 4.760.5 ± 5.6109.7 ± 24.5
Fasting plasma FFA (mmol/l)0.7 ± 0.10.8 ± 0.11.2 ± 0.1
Clamp
 GDR (mg · kg FFM−1 · min−1)16.6 ± 1.611.0 ± 1.5*4.5 ± 1.9*
 Blood glucose (mmol/l)4.9 ± 0.15.1 ± 0.15.0 ± 0.1
 Plasma insulin (pmol/l)429 ± 35545 ± 36522 ± 35
  • Data are means ± SE.

  • *

    * Different compared with young healthy subjects (P < 0.05);

  • different compared with diabetic subjects (P < 0.05).