TABLE 1

Genotype and allele frequencies of the examined variants in SLC2A10 among type 2 diabetic patients and glucose-tolerant subjects

Type 2 diabetic patientsGlucose-tolerant subjectsPAFPGD
−27C→T
C/C466 (97)488 (98)
C/T13 (3)12 (2)
T/T0 (0)0 (0)
Allele frequency1.4 (0.6–2.1)1.2 (0.5–1.9)0.80.8
Ala206Thr
Ala/Ala455 (91)469 (92)
Ala/Thr42 (8)36 (7)
Thr/Thr2 (0)2 (0)
Allele frequency4.6 (3.3–5.9)3.9 (2.7–5.1)0.50.8
IVS2 + 10G→A
G/G450 (96)474 (97)
G/A20 (4)15 (3)
A/A1 (0)1 (0)
Allele frequency2.3 (1.4–3.3)1.7 (0.9–2.6)0.40.7
IVS4 + 18T→G
T/T162 (33)174 (40)
T/G248 (50)190 (43)
G/G85 (17)73 (17)
Allele frequency42.2 (39.1–45.3)38.4 (35.2–41.7)0.10.07
  • Data are number of subjects with each genotype (% of each group) and allele frequencies of minor allele in % (95% CI). The P values compare allele frequencies (PAF) and genotype distributions (PGD) between type 2 diabetic patients and glucose-tolerant subjects. All genotype groups obeyed Hardy-Weinberg equilibrium.