TABLE 2

Anthropometric and metabolic characteristics of 510 glucose-tolerant Danish white subjects stratified according to SLC2A10 Ala206Thr genotype

Ala206ThrAla/AlaAla/Thr + Thr/ThrP
n (men/women)469 (217/252)38 (20/18)
Age (years)56 ± 1058 ± 9
BMI (kg/m2)25.7 ± 3.726.0 ± 3.40.8
Plasma glucose
 Fasting (mmol/l)5.1 ± 0.45.0 ± 0.40.2
 30-min post-OGTT (mmol/l)7.7 ± 1.47.8 ± 1.41.0
 60-min post-OGTT (mmol/l)7.5 ± 1.97.4 ± 2.10.6
 120-min post-OGTT (mmol/l)5.4 ± 1.25.5 ± 1.20.7
 Post-OGTT AUC (min · mmol/l)195 ± 119206 ± 1310.8
Serum insulin
 Fasting (pmol/l)39 ± 1932 ± 170.002
 30-min post-OGTT (pmol/l)261 ± 148217 ± 1220.03
 60-min post-OGTT (pmol/l)310 ± 194276 ± 2170.05
 120-min post-OGTT (pmol/l)183 ± 123163 ± 1170.2
 Post-OGTT AUC (min · pmol/l)23,021 ± 12,93320,397 ± 14,3580.04
 Insulinogenic index29.0 ± 17.923.2 ± 11.80.03
  • Data are means ± SD. Values of insulin or values derived from insulin were logarithmically transformed before statistical analysis. Calculated P values were adjusted for age, sex, and BMI and were calculated assuming a dominant model for the penetrance of the Thr allele. The insulinogenic index was calculated as fasting serum insulin (pmol/l) subtracted from 30-min post-OGTT serum insulin (pmol/l) and divided by 30-min post-OGTT plasma glucose (mmol/l).