TABLE 1

Functional and structural data from all groups

Control groupCAG (0–32 weeks)CALT (16–32 weeks)Diabetic groupDAG (0–32 weeks)DALT (16–32 weeks)
Plasma glucose (mmol/l)6.3 ± 0.25.9 ± 0.16.3 ± 0.128.4 ± 1.5*30.0 ± 1.4*26.9 ± 1.6*
HbA1c (%)4.5 ± 0.24.0 ± 0.25.9 ± 0.215.2 ± 0.8*14.7 ± 0.9*15.9 ± 0.7*
AER (mg/24 h)
    Week 161.6 (1.5−1.7)0.6 (0.5−1.5)0.9 (0.6−1.6)7.9 (4.8−21.6)*1.6 (1.0−3.1)8.5 (5.7−14.5)*
    Week 323.9 (2.2−10.6)1.5 (0.6−3.2)§8.0 (3.6−9.4)59.7 (31.6−88.0)*3.4 (1.7−7.9)21.8 (11.1−32.6)
Mean systolic blood pressure (mmHg)115 ± 5116 ± 7114 ± 6161 ± 4*142 ± 6*145 ± 6*
Glomerular filtration rate (ml · min−1 · g kidney wt−12.2 ± 0.21.8 ± 0.22.4 ± 0.12.6 ± 0.1#2.8 ± 0.2#2.3 ± 0.2
Kidney−to−body weight ratio (×10−3)2.9 ± 0.12.7 ± 0.22.9 ± 0.15.7 ± 0.2*5.2 ± 0.4*††5.0 ± 0.2*
Renal AGEs (% area)7.7 ± 0.47.3 ± 1.68.1 ± 0.914.9 ± 0.6*8.3 ± 0.87.2 ± 0.7
  • Data are means ± SE or median (interquartile range). Data for renal AGEs represent morphometric computer-aided analysis of renal cortical AGE (CML) immunostaining.

  • *

    * P < 0.001 vs control group;

  • P < 0.001 vs diabetic group;

  • P < 0.001 for DAG vs. DALT;

  • §

    § P < 0.001 vs. CALT;

  • P < 0.01 vs. diabetic group;

  • P < 0.05 vs. DAG;

  • #

    # P < 0.05 vs. control group;

  • ††

    †† P < 0.05 vs. diabetic group.