Functional and structural data from all groups
Control group | CAG (0–32 weeks) | CALT (16–32 weeks) | Diabetic group | DAG (0–32 weeks) | DALT (16–32 weeks) | |
---|---|---|---|---|---|---|
Plasma glucose (mmol/l) | 6.3 ± 0.2 | 5.9 ± 0.1 | 6.3 ± 0.1 | 28.4 ± 1.5* | 30.0 ± 1.4* | 26.9 ± 1.6* |
HbA1c (%) | 4.5 ± 0.2 | 4.0 ± 0.2 | 5.9 ± 0.2 | 15.2 ± 0.8* | 14.7 ± 0.9* | 15.9 ± 0.7* |
AER (mg/24 h) | ||||||
Week 16 | 1.6 (1.5−1.7) | 0.6 (0.5−1.5) | 0.9 (0.6−1.6) | 7.9 (4.8−21.6)* | 1.6 (1.0−3.1)†‡ | 8.5 (5.7−14.5)* |
Week 32 | 3.9 (2.2−10.6) | 1.5 (0.6−3.2)§ | 8.0 (3.6−9.4) | 59.7 (31.6−88.0)* | 3.4 (1.7−7.9)† | 21.8 (11.1−32.6)†‖ |
Mean systolic blood pressure (mmHg) | 115 ± 5 | 116 ± 7 | 114 ± 6 | 161 ± 4* | 142 ± 6*¶ | 145 ± 6*¶ |
Glomerular filtration rate (ml · min−1 · g kidney wt−1 | 2.2 ± 0.2 | 1.8 ± 0.2 | 2.4 ± 0.1 | 2.6 ± 0.1# | 2.8 ± 0.2# | 2.3 ± 0.2 |
Kidney−to−body weight ratio (×10−3) | 2.9 ± 0.1 | 2.7 ± 0.2 | 2.9 ± 0.1 | 5.7 ± 0.2* | 5.2 ± 0.4*†† | 5.0 ± 0.2*¶ |
Renal AGEs (% area) | 7.7 ± 0.4 | 7.3 ± 1.6 | 8.1 ± 0.9 | 14.9 ± 0.6* | 8.3 ± 0.8† | 7.2 ± 0.7† |
Data are means ± SE or median (interquartile range). Data for renal AGEs represent morphometric computer-aided analysis of renal cortical AGE (CML) immunostaining.
* P < 0.001 vs control group;
† P < 0.001 vs diabetic group;
‡ P < 0.001 for DAG vs. DALT;
§ P < 0.001 vs. CALT;
¶ P < 0.01 vs. diabetic group;
‖ P < 0.05 vs. DAG;
# P < 0.05 vs. control group;
†† P < 0.05 vs. diabetic group.