TABLE 1

In vivo body composition in diet-induced obese mice at baseline, 24 h, and 6 days after CNTFAx15 administration for 3 days (0.1 and 1.0 μg · g−1 · day−1, respectively)

GroupsTotal fat tissue mass (g)Total lean tissue mass (g)Total body fat (%)Abdominal fat tissue mass (g)Abdominal lean tissue mass (g)Abdominal body fat (%)
Baseline
    PBS21.7 ± 1.122.0 ± 0.749.5 ± 1.49.9 ± 0.49.4 ± 0.451.2 ± 0.9
    C-0.121.5 ± 1.221.2 ± 0.649.3 ± 1.19.0 ± 0.48.9 ± 0.350.0 ± 1.0
    C-1.020.1 ± 0.621.9 ± 0.547.7 ± 0.89.5 ± 0.49.8 ± 0.349.2 ± 0.7
    PF to C-1.021.1 ± 0.720.9 ± 0.550.2 ± 0.910.0 ± 0.49.2 ± 0.351.4 ± 1.0
24 h after last treatment
    PBS18.6 ± 0.719.8 ± 0.548.3 ± 1.28.3 ± 0.38.7 ± 0.349.0 ± 0.9
    C-0.117.0 ± 0.918.7 ± 0.547.3 ± 1.87.9 ± 0.57.9 ± 0.449.7 ± 1.5
    C-1.015.7 ± 0.7*17.8 ± 0.446.8 ± 1.47.2 ± 0.2*§7.3 ± 0.249.5 ± 0.9
    PF to C-1.017.2 ± 0.619.6 ± 0.446.7 ± 0.98.4 ± 0.38.8 ± 0.248.7 ± 1.0
6 days after last treatment
    PBS16.9 ± 0.622.0 ± 0.648.5 ± 1.08.3 ± 0.39.9 ± 0.550.9 ± 0.8
    C-0.114.7 ± 0.820.6 ± 0.4§46.6 ± 1.66.4 ± 0.4*#8.8 ± 0.248.3 ± 1.4
    C-1.012.2 ± 0.6**††22.2 ± 0.440.3 ± 1.2**§5.9 ± 0.3**††10.2 ± 0.341.6 ± 1.1**††
    PF to C 1.016.2 ± 0.622.8 ± 0.346.4 ± 1.07.8 ± 0.310.2 ± 0.448.2 ± 0.9
  • Data are means ± SE, analyzed by unpaired t test.

  • *

    * P < 0.01,

  • P < 0.05 vs. the PBS-treated group;

  • P < 0.05,

  • §

    § P < 0.01 vs. the pair-fed group;

  • P < 0.05,

  • P < 0.01 vs. the 1.0 μg·g−1·day−1 CNTFAx15-treated group;

  • #

    # 0.07 < P < 0.05,

  • **

    ** P < 0.0001 vs. the PBS-treated group;

  • ††

    †† P < 0.0001 vs. the pair-fed group. C-0.1, 0.1 μg·g−1·day−1 CNTFAx15-treated group; C-1.0, 1.0 μg·g−1·day−1 CNTFAx15-treated group; PF, pair-fed.