Type 1 diabetic family collection | Transmitted | Untransmitted* | RR (95% CI) | P |
---|---|---|---|---|

Allele T/Trp^{620} (TDT) | 565 | 339 | 1.67 (1.46–1.91) | 5.62 × 10^{−14} |

Genotypes | ||||

C/C | 1,364 (70.1) | 4,448 (76.2) | 1.00 (reference) | — |

C/T | 516 (26.5) | 1,288 (22.1) | 1.61 (1.38–1.87) | 9.96 × 10^{−10} |

T/T | 66 (3.4) | 102 (1.7) | 3.13 (2.18–4.48) | 5.30 × 10^{−10} |

Type 1 diabetes case-control collection | Case subjects | Control subjects | OR (95% CI) | P |
---|---|---|---|---|

Alleles | ||||

C | 2,610 (83.0) | 3,077 (89.6) | 1.00 (reference) | — |

T | 536 (17.0) | 359 (10.4) | 1.78 (1.54–2.06) | 1.17 × 10^{−14} |

Genotypes | ||||

C/C | 1,077 (68.5) | 1,377 (80.2) | 1.00 (reference) | — |

C/T | 456 (29.0) | 323 (18.8) | 1.81 (1.53–2.13) | 1.34 × 10^{−12} |

T/T | 40 (2.5) | 18 (1.0) | 2.84 (1.62–4.98) | 2.73 × 10^{−4} |

Data are

*n*(%), unless noted otherwise. For the case-control collection, using logistic regression, we assumed a multiplicative model (likelihood-ratio test, χ_{1}^{2}= 61.57,*P*= 4.22 × 10^{−15}) because it was not significantly different (likelihood-ratio test, χ_{1}^{2}= 0.18,*P*= 0.67) from the full genotype model (likelihood-ratio test, χ_{2}^{2}= 61.75,*P*= 3.90 × 10^{−14}) (19).- *
* Untransmitted (pseudocontrol) data for genotypes in the type 1 diabetic family collection are estimated, using conditional logistic regression, as in Cordell and Clayton (19). TDT, transmission/disequilibrium test.