TABLE 1

The 1858C>T/Trp620 allele and genotype frequencies and association test results in the type 1 diabetic family and case-control collections

Type 1 diabetic family collectionTransmittedUntransmitted*RR (95% CI)P
Allele T/Trp620 (TDT)5653391.67 (1.46–1.91)5.62 × 10−14
Genotypes
C/C1,364 (70.1)4,448 (76.2)1.00 (reference)
C/T516 (26.5)1,288 (22.1)1.61 (1.38–1.87)9.96 × 10−10
T/T66 (3.4)102 (1.7)3.13 (2.18–4.48)5.30 × 10−10
Type 1 diabetes case-control collectionCase subjectsControl subjectsOR (95% CI)P
Alleles
C2,610 (83.0)3,077 (89.6)1.00 (reference)
T536 (17.0)359 (10.4)1.78 (1.54–2.06)1.17 × 10−14
Genotypes
C/C1,077 (68.5)1,377 (80.2)1.00 (reference)
C/T456 (29.0)323 (18.8)1.81 (1.53–2.13)1.34 × 10−12
T/T40 (2.5)18 (1.0)2.84 (1.62–4.98)2.73 × 10−4
  • Data are n (%), unless noted otherwise. For the case-control collection, using logistic regression, we assumed a multiplicative model (likelihood-ratio test, χ12 = 61.57, P = 4.22 × 10−15) because it was not significantly different (likelihood-ratio test, χ12 = 0.18, P = 0.67) from the full genotype model (likelihood-ratio test, χ22 = 61.75, P = 3.90 × 10−14) (19).

  • *

    * Untransmitted (pseudocontrol) data for genotypes in the type 1 diabetic family collection are estimated, using conditional logistic regression, as in Cordell and Clayton (19). TDT, transmission/disequilibrium test.