TABLE 2

Population PTPN22/LYP1858C>T parental allele frequencies and transmission-disequilibrium test results for allele T/Trp620

PopulationNo. of parent-child triosParental allele frequency (%)TransmittedUntransmittedRR (95% CI)P
U.K.*1,08714.33382041.66 (1.40–1.98)8.6 × 10−9
Great Britain85016.42721751.55 (1.28–1.87)4.5 × 10−6
Northern Ireland23712.366292.28 (1.47–3.53)1.5 × 10−4
U.S.62612.91731001.73 (1.35–2.21)1.0 × 10−5
Romania23310.254351.54 (1.01–2.36)0.04
  • *

    * Combined result for Great Britain and Northern Ireland.