TABLE 4

PTPN22/LYP 1858C>T/Trp620 allele and genotype frequencies and association test results in the Graves’ disease case-control collection

Case subjectsControl subjectsLogistic regression
OR (95% CI)P
Alleles
    C1,544 (85.7)1,492 (89.6)1.00 (reference)
    T258 (14.3)174 (10.4)1.43 (1.17–1.76)6.26 × 10−4
Genotypes
    C/C661 (73.4)669 (80.3)1.00 (reference)
    C/T222 (24.6)154 (18.5)1.46 (1.16–1.84)1.42 × 10−3
    T/T18 (2.0)10 (1.2)1.82 (0.83–3.98)0.132
  • Data are n (%), unless noted otherwise. We assumed a multiplicative model (likelihood-ratio test, χ12 = 11.95, P = 5.46 × 10−4) because it was not significantly different (likelihood-ratio test, χ12 = 0.12, P = 0.73) from the full genotype model (likelihood-ratio test, χ22 = 12.06, P = 2.41 × 10−3) (19).