TABLE 2

Metabolic and hemodynamic variables before and during hyperinsulinemia in lean women: effects of FFA elevation versus saline infusion (control)

Saline infusion
FFA elevation
Basal stateSalineSaline + insulinBasal stateFFAFFA + insulin
Blood glucose (mmol/l)4.3 ± 0.44.2 ± 0.44.9 ± 0.4*4.4 ± 0.54.2 ± 0.45.0 ± 0.4*
Plasma insulin (pmol/l)26 ± 1223 ± 10391 ± 75*26 ± 1028 ± 11417 ± 67*
Plasma FFA + THL (mmol/l)0.55 ± 0.190.58 ± 0.220.01 ± 0.01*0.52 ± 0.170.91 ± 0.19§0.40 ± 0.13*§
M/I value ×100 (mg · kg−1 · min−1 per pmol/l)2.17 ± 0.971.59 ± 0.94
Systolic blood pressure (mmHg)117 ± 14119 ± 16117 ± 12115 ± 10118 ± 15121 ± 13
Diastolic blood pressure (mmHg)65 ± 966 ± 1063 ± 765 ± 871 ± 1266 ± 10
Heart rate (bpm)66 ± 1168 ± 1168 ± 2167 ± 1068 ± 1177 ± 15*
  • Data are means ± SD.

  • *

    * P < 0.01 vs. FFA and vs. saline;

  • P < 0.05 change from basal state during FFA elevation vs. during saline infusion;

  • P < 0.01 vs. basal state;

  • §

    § P < 0.01 change from basal state during FFA elevation vs. during saline infusion;

  • P < 0.05 FFA elevation vs. saline infusion;

  • P = 0.09 change from basal state during FFA elevation vs. during saline infusion. THL, tetrahydrolipostatin.