TABLE 3

Metabolic and hemodynamic variables before and during hyperinsulinemia in obese women: effects of FFA lowering versus placebo

Placebo
FFA lowering
Basal stateInsulinBasal stateInsulin
Blood glucose (mmol/l)4.7 ± 0.85.0 ± 0.24.7 ± 0.85.1 ± 0.2
Plasma insulin (pmol/l)89 ± 33483 ± 187*49 ± 17509 ± 160*
Plasma FFA (mmol/l)0.69 ± 0.210.06 ± 0.10*0.18 ± 0.100.02 ± 0.03*
M/I value ×100 (mg · kg−1 · min−1 per pmol/l)0.52 ± 0.340.62 ± 0.28§
Systolic blood pressure (mmHg)128 ± 8135 ± 8129 ± 14139 ± 15*
Diastolic blood pressure (mmHg)70 ± 974 ± 970 ± 1176 ± 9*
Heart rate (bpm)70 ± 680 ± 6*71 ± 679 ± 5*
  • Data are means ± SD.

  • *

    * P < 0.01 vs. basal state;

  • P < 0.01 FFA lowering vs. placebo;

  • P < 0.01 change from basal state with FFA lowering vs. with placebo;

  • §

    § P = 0.06 FFA lowering vs. placebo;

  • P < 0.05 vs. basal state.