TABLE 4

Microvascular measurements before and during hyperinsulinemia in lean women: effects of FFA elevation versus saline infusion (control)

Saline infusion
FFA elevation
Basal stateSalineSaline + insulinBasal stateFFAFFA + insulin
Perfused capillary density
    Baseline density (caps/mm2)38.2 ± 4.538.2 ± 5.938.2 ± 6.736.1 ± 6.235.9 ± 6.336.1 ± 7.1
    Peak density (caps/mm2)58.1 ± 8.258.4 ± 5.063.8 ± 9.6*55.4 ± 11.451.3 ± 9.955.1 ± 10.3§
    Percentage increase (%)55.5 ± 21.256.9 ± 18.972.4 ± 25.1*54.2 ± 19.344.6 ± 16.854.0 ± 21.3*
Ach-mediated vasodilation
    Baseline perfusion (PU)24.0 ± 7.325.4 ± 7.025.6 ± 10.023.1 ± 6.028.3 ± 11.134.6 ± 14.1
    Plateau (PU)146.0 ± 58.7162.3 ± 54.4199.3 ± 88.3155.9 ± 56.1126.5 ± 68.8128.2 ± 79.5
    Percentage increase (%)516 ± 164557 ± 162685 ± 199*579 ± 201338 ± 131#264 ± 186
SNP-mediated vasodilation
    Baseline perfusion (PU)32.0 ± 12.328.8 ± 11.131.9 ± 16.430.8 ± 12.631.8 ± 10.934.8 ± 12.4
    Plateau (PU)166.6 ± 81.3155.3 ± 56.5160.1 ± 60.3161.9 ± 63.1132.1 ± 55.1153.2 ± 52.1
    Percentage increase (%)461 ± 277490 ± 291450 ± 220426 ± 334362 ± 244405 ± 274
  • Data are means ± SD.

  • *

    * P < 0.01 vs. FFA and vs. saline;

  • P < 0.05 vs. basal state;

  • P < 0.05 change from basal state during FFA elevation vs. during saline infusion;

  • §

    § P < 0.05 vs. FFA and vs. saline;

  • P < 0.01 and

  • P = 0.09 change from basal state during FFA elevation vs. during saline infusion;

  • #

    # P < 0.01 vs. basal state. Ach, acetylcholine; caps, number of perfused capillaries; PU, arbitrary perfusion units; SNP, sodium nitroprusside.